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FLASH GENE
Symbol DIRAS3 contributors: mct - updated : 02-10-2013
HGNC name DIRAS family, GTP-binding RAS-like 3
HGNC id 687
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • small G protein, containing three motifs typical of the Ras/Rap family members,i.e.
  • a highly conserved GTP binding domain
  • a putative effector domain
  • the membrane localization CAAX motif
  • HOMOLOGY
    intraspecies homolog to RAP2A
    Homologene
    FAMILY Ras/Rap oncogene superfamily member
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers and whose reactivation is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation
  • plays a particularly important role in ovarian cancer cell migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interact with STAT3, and changes in DIRAS3 expression might therefore affect transcription of STAT3 target genes
  • interacts with RAF1 to specifically suppress the activating phosphorylations on MEK and ERK, thus restricting migration of non-cancer cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOI    
    epigenetically silenced in cancer cell lines
    tumoral     --low  
    in breast cancer
    tumoral     --low  
    in > 60p100 of ovarian cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS