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FLASH GENE
Symbol EFNA2 contributors: mct - updated : 04-02-2012
HGNC name ephrin-A2
HGNC id 3222
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence
  • a receptor-binding region
  • a spacer region
  • a hydrophobic region
  • HOMOLOGY
    Homologene
    FAMILY ephrin family
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text anchored to the membrane by a glycosylphosphatidylinositol linkage
    basic FUNCTION
  • playing a key role in controlling cell movements in many tissues and at multiple stages of patterning
  • EFNA2 and EPHA7 as negative regulators of progenitor cell proliferation
  • EFNA2, EFNA3, EFNA5, and neural activity act together to control patterning of eye-specific retinogeniculate layers
  • playing a specific role in postnatal neurogenesis
  • bidirectional EFNA2-EPHA2 signaling regulates bone remodeling at the initiation phase
  • EFNA1 and EFNA2, but not the EFNA3, EFNA4, EFNA5 cluster, regulate the members of the ubiquitin-associated proteolysis genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPHA7
  • binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5
  • EFNA2-EPHA2 interaction facilitates the initiation phase of bone remodeling by enhancing osteoclast differentiation and suppressing osteoblast differentiation
  • cell & other
    REGULATION
    induced by rapidly induced by receptor activator of NF-kappaB ligand in osteoclast precursors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Efna2(-/-) mice have abnormal topography in the primary visual system but have normal visual and learning performance on a simple visual discrimination task