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FLASH GENE
Symbol CA11 contributors: mct/npt - updated : 16-07-2008
HGNC name carbonic anhydrase XI
HGNC id 1370
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • missing the three His essential for catalytic activity
  • a sequence homologous to the frog neuropeptide sauvagine
  • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    intraspecies homolog to acatalytic carbonic anhydrase peptide VIII and X
    Homologene
    FAMILY
  • alpha-carbonic anhydrase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • E3 ligases that target TP53 as well as phospho-TP53 for degradation
  • play roles in various biological process of the CNS
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • target SFN for degradation, leading to MDM2 stabilization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    enhancing MDM2/MDMX interaction
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS