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FLASH GENE
Symbol USP13 contributors: mct - updated : 22-05-2016
HGNC name ubiquitin specific protease 13 (isopeptidase T-3)
HGNC id 12611
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two UBA domains
  • an UBP-type zinc finger
  • an Ub-binding domains implicated in regulatory catalysis by biochemical and NMR structural approaches
  • HOMOLOGY
    Homologene
    FAMILY peptidase C19 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in ubiquitin-dependent protein catabolism
  • regulating SIAH2 ligase stability and activity via noncatalytic ubiquitin-binding domains
  • responsible for MITF deubiquitination, utilizing a short hairpin RNA library against known deubiquitinating enzymes
  • may function differently from USP5 in cellular deubiquitination processes
  • USP13 is a AMFR-associated DUB that eliminates ubiquitin conjugates from UBL4A to maintain the functionality of BAG6
  • USP5 regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains while USP13 regulates stress granules through deubiquitylating protein-conjugated ubiquitin chains
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SIAH2
  • through deubiquitination, USP13 stabilizes and upregulates MITF protein levels)
  • interacting with BECN1 (Beclin1 controls the protein stabilities of USP10 and USP13 by regulating their deubiquitinating activities)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    might be a viable therapeutic target for melanoma
    ANIMAL & CELL MODELS