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FLASH GENE
Symbol TULP3 contributors: mct - updated : 18-04-2011
HGNC name tubby like protein 3
HGNC id 12425
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • two nuclear localization signals (NLS), AA 37-40, AA 258-61
  • the first overlapping a motif of glutamines flanked by basic residues, modifying the NLS to a nucleolar localization signal, also containing a stretch of 15 predominantly hydrophobic flanked by charged residues and reminiscent of a membrane anchor domain
  • HOMOLOGY
    interspecies homolog to murine Tulp3
    intraspecies homolog to TUB
    Homologene
    FAMILY tubby-like gene family
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • membrane bound transcription regulator
  • function as membrane-bound transcription regulators that translocate to the nucleus in response to phosphoinositide hydrolysis, providing a direct link between G-protein signaling and the regulation of gene expression
  • potential role as a negative regulatory factor in the Hh pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to the IFT-A complex, linked to retrograde ciliary transport, but, surprisingly, the IFT-A complex has a second role directing ciliary entry of TULP3
  • TULP3-IFT-A interaction suggests how these proteins cooperate during neural tube patterning
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Tulp3(-/-) murine embryos show expansion of Shh target gene expression and display a ventralization of neural progenitor cells in the caudal neural tube