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FLASH GENE
Symbol DYRK3 contributors: mct/npt/pgu - updated : 14-04-2015
HGNC name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
HGNC id 3094
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain of DYRK3 contains a predicted low complexity sequence, which may allow partitioning into stress granules and contribute to liquid-liquid unmixing
  • a canonical kinase domain between a large N terminal region
  • a short C terminal extension
  • HOMOLOGY
    interspecies homolog to murine Dyrk3 (89.9pc)
    homolog to rattus Dyrk3 (91.1pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • MNB/DYRK subfamily
  • CATEGORY enzyme , receptor membrane serine/threonine tyrosine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • also at least partially localized in the nucleus
  • DYRK3 localizes to Stress granules during oxidative and osmotic stress
  • basic FUNCTION
  • serine/threonine and tyrosine kinase, phosphorylating histone H2B, putatively involved in cell growth and development
  • might act to attenuate erythroblast development
  • attenuates (and possibly apportions) red cell production selectively during anemia
  • may act via intrinsic erythroid cell mechanisms to selectively place an upper limit on stress erythropoiesis
  • promotes cell survival through pphosphorylation and activation of SIRT1 with DYRK1A
  • regulates erythropoiesis through as yet unknown molecular pathways
  • DYRK1A, DYRK3, DYRK4 implicated in the regulation of cytoskeletal organization and process outgrowth in neurons
  • during cellular stress the dual specificity kinase DYRK3 regulates the stability of P-granule-like structures and MTOR signaling
  • displays a cyclic partitioning mechanism between stress granules and the cytosol via a low-complexity domain in its N terminus and its kinase activity
  • dynamically regulates its own partitioning between stress granules and the cytosol through its kinase activity, suggesting a cyclic partitioning mechanism that couples compartmentalization through liquid phase transition with cellular signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DCX is likely one relevant DYRK1A, DYRK3, DYRK4 target
  • when DYRK3 is active, it allows stress granule dissolution, releasing MTOR for signaling and promoting its activity by directly phosphorylating the MTOR inhibitor AKT1S1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS