basic FUNCTION
| serine/threonine and tyrosine kinase, phosphorylating histone H2B, putatively involved in cell growth and development |
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might act to attenuate erythroblast development |
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attenuates (and possibly apportions) red cell production selectively during anemia |
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may act via intrinsic erythroid cell mechanisms to selectively place an upper limit on stress erythropoiesis |
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promotes cell survival through pphosphorylation and activation of SIRT1 with DYRK1A |
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regulates erythropoiesis through as yet unknown molecular pathways |
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DYRK1A, DYRK3, DYRK4 implicated in the regulation of cytoskeletal organization and process outgrowth in neurons |
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during cellular stress the dual specificity kinase DYRK3 regulates the stability of P-granule-like structures and MTOR signaling |
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displays a cyclic partitioning mechanism between stress granules and the cytosol via a low-complexity domain in its N terminus and its kinase activity |
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dynamically regulates its own partitioning between stress granules and the cytosol through its kinase activity, suggesting a cyclic partitioning mechanism that couples compartmentalization through liquid phase transition with cellular signaling |