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FLASH GENE
Symbol TNFRSF17 contributors: mct - updated : 19-01-2016
HGNC name tumor necrosis factor receptor superfamily, member 17
HGNC id 11913
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracytoplasmic cysteine-rich pseudorepeats typical for the TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic tail
  • a DEATH domain
  • mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY tumor necrosis factor receptor superfamily
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 3 membrane protein
    basic FUNCTION
  • receptor of TNSF13B promoting B-cell survival and playing a role in the regulation of humoral immunity
  • is an inflammation-related TNFSFR member in keratinocytes, of potential importance in the management of inflammatory skin conditions
  • is mostly known for its functional activity in mediating the survival of plasma cells that maintain long-term humoral immunity
  • essential membrane protein for maintaining the survival of plasma cells, identified as a glycoprotein exhibiting complex-type N-glycans at a single N-glycosylation site, asparagine 42
  • importance of N-glycosylation on TNFRSF17 in the regulation of ligand binding and functions of plasma cells
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TNFSF13 binding to TNFRSF17 decreases cell proliferation by inducing G(2)/M cell cycle arrest
  • ELL2 enhances the expression of TNFRSF17, which is important for long-term survival
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in primary Sjogren syndrome
    tumoral   translocation    
    T cell malignant lymphoma with t(4;16)(q26;p13)
    constitutional     --over  
    with TNF, TNFSF13B, TNFSF13 in Behcet disease
    constitutional     --over  
    in inflammatory skin lesions of psoriasis
    tumoral     --over  
    in skin squamous cell carcinomas
    constitutional     --over  
    in systemic lupus erythematosus (SLE)
    Susceptibility to UC (ulcerative colitis) and IBD (inflammatory bowel disease)
    Variant & Polymorphism other
  • haplotypes of the TNFRSF17 polymorphisms might be associated with UC and IBD susceptibility
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    BCMA-/- knockout mice,developing systemic lupus erythematosis