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FLASH GENE
Symbol TBL2 contributors: mct - updated : 30-06-2015
HGNC name transducin (beta)-like 2
HGNC id 11586
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal transmembrane region
  • four putative WD40 repeats, bipartite nuclear localization signal (NLS) and a consensus leucine zipper domain
  • C-terminal WD40 domain
  • HOMOLOGY
    interspecies ortholog to murine Tbl2
    Homologene
    FAMILY beta-transductin protein family
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text TBL2 was predominantly mitochondrial
    basic FUNCTION intracellular signaling pathway
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • UBIAD1-TBL2 complex likely functions in oxidative/nitrosative stress, lipid metabolism
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between UBIAD1 and TBL2 proteins (UBIAD1 was localized to both mitochondrial and non-mitochondrial membranes whereas TBL2 was predominantly mitochondrial)
  • serves as a potential regulator of the EIF2AK3 pathway
  • TBL2 interacts with PKR-like ER-resident kinase (EIF2AK3), and under ER stress, it mediates protein expression of activating transcription factor 4 (ATF4)
  • under ER stress, TBL2 participates in ATF4 translation through its association with the mRNA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in Williams-Beuren syndrome with other genes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS