basic FUNCTION
| a functional paracrine/autocrine role in osteoarthritis -affected cartilage ( |
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role in the processing of cell surface proteins TNF receptor, the L-selectin adhesion molecule, and transforming growth factor-alpha ( |
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an essential role mammalian development ( |
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role in the regulated shedding of EGFR ligands ( |
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acts as alpha-secretases in A172 cells ( |
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functions as an effector of GPCR-mediated signalling and represents a key element of the cellular receptor cross-talk network ( |
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mediating the cleavage and shedding of fraktalkine (CX3CL1) |
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releasing TNFA from its membrane bound precursor, also reported to cleave APP |
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contributing to heart development |
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growth hormone binding protein sheddase (see GHR) |
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metalloprotease disintegrin cleaving a variety of membrane proteins, releasing ("shedding") their extracellular domains from cells |
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playing a role in the regulation of platelet glycoprotein V |
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may be having a role in both the induction and down-regulation of neutrophil activity |
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involved in invasion of oral squamous cell carcinoma, probably through CD44 cleavage |
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being responsible with ADAM10 for the cytokine-induced shedding of CXCL16 |
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involved in the tumor-associated proteolytic release of soluble MICA facilitating tumor immune escape ( |
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important regulator of several key steps during angiogenesis |
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involved in the conversion of MMP2 from the latent form to the intermediate-sized form and plays a particularly key role in the conversion of the intermediate-sized form to the fully activated form |
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may regulate angiogenesis via its effects on endothelial cells proliferation, network formation, invasion and MMP2 activation |
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involved in the cleavage of NOTCH1 |
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is required for NOTCH1 signaling independent of ligands |
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mediates inflammation-induced shedding of SDC1 and SDC4 by lung epithelial cells |
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responsible for cleaving the membrane-proximal extracellular domain of L-selectin, which reduces the efficiency of leucocyte recruitment to sites of inflammation |
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shedding JAG1 in a lipid-raft-independent manner, and the cytosolic domain of the former protein is not a pre-requisite for either constitutive or regulated shedding |
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through the cleavage of VASN, the metalloprotease controls TGFB-mediated epithelial-to-mesenchymal transition |
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cleaves neuregulin-1 type III in the epidermal growth factor domain and negatively regulates peripheral nervous system myelination ( |
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a modulator of NRG1 type III activity and is a negative regulator of myelination in the peripheral nervous system ( |
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its induction during apoptosis may rapidly diminish neutrophil sensitivity to the inflammatory environment, complementing other anti-inflammatory activities by these cells during inflammation resolution |
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may play a broad role in the homeostatic maintenance of various substrates in the blood |
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is a novel UPR-regulated gene in response to severe hypoxia and ER stress, which is actively involved in the release of TNFRSF1A under these conditions |
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potential functional link between ADAM17 and ICOSLG in controlling adaptive immune responses |
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ADAM10 and ADAM17 have opposite effects on sprouting angiogenesis that may be unrelated to Notch signalling and involves differentially expressed anti-angiogenic proteins such as TSP1 |
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both ADAM10 and ADAM17 are associated with FASLG-containing secretory lysosomes |
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ADAM17 has a prominent role in ANCA-associated vasculitis (AAV) and might account for the vascular complications associated with this disease |
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ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function |
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is regarded as a first line of defense against injury and infection, by releasing tumor necrosis factor alpha (TNF) to promote inflammation and epidermal growth factor (EGF) receptor ligands to maintain epidermal barrier function |
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PDIA6 regulation of ADAM17 shedding activity and EGFR-mediated migration and invasion of glioblastoma cells |
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ADAM17 central role in signalling implies that ADAM17 activity has to be tightly regulated, including at the level of localisation |
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regulation of the shedding activity of ADAM17 is multilayered and different regions of the protease are involved |
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inhibition of ADAM17 in cortical lesions favors neuronal formation by promoting the differentiation of progenitors and by facilitating migration of neuroblasts from the subventricular zone (SVZ) towards the injured area |
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implicated in many shedding processes |
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importance of ADAM17 on podosome disassembly and thus cell motility and normal cell function of macrophages |