basic FUNCTION
| PKC apoptosis WT1 regulator |
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transcriptional repressor activity |
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contributes to apoptotic neuronal cell death in Alzeihmer disease |
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regulated choline up-take via its interaction with CHT1 |
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may be a mediator of neuronal apoptosis in HIV encephalitis |
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regulatory component in the dopamine signaling, constituting a molecular link between impaired dopamine signaling and depression |
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in addition to its proapoptotic function, acts as a novel transcription cofactor for AR to target CFLAR gene expression |
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proapoptotic protein with intracellular functions in the cytoplasm and nucleus |
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activates an extrinsic pathway involving cell surface HSPA5 for induction of apoptosis and is essential for its cell surface expression |
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PITX2-interacting protein that regulates PITX2 activity in ocular cells |
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unique proapoptotic protein that selectively induces apoptosis in cancer cells, sensitizes cells to the action of multiple apoptotic stimuli, and causes tumor regression through a region harboring 59-AAs starting from 145 to 203 |
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act at multiple levels that include activating both the FAS- and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-controlled proapoptotic pathways, as well as inhibiting the NF-{kappa}B antiapoptotic pathway |
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implicated in the regulation of smooth muscle contraction |
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is expressed in trophoblastic cells and is involved in transport of HSPA5 to the cell surface and thus regulates invasive property of extravillous cytotrophoblastic cells (CTB) |
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is a novel and essential downstream target of TGFB1 signaling and acts as an important factor during TGFB1-induced EMT |
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importance of PAWR not only in preventing cancer development/recurrence but also as a promising anticancer therapeutic agent |
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intrinsically disordered pro-apoptotic protein with tumour suppressor function |
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induces cancer cell apoptosis through endoplasmic reticulum (ER) stress and mitochondrial dysfunction |
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novel role for PAWR/NFKB1 in islet beta cell apoptosis and type 2 diabetes |
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is a tumor-suppressor that has been shown to induce cancer-cell selective apoptosis in a variety of cancers |
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proapoptotic protein (PAWR/Par-4) negatively regulates residual cancer cell survival and recurrence |