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FLASH GENE
Symbol S1PR4 contributors: npt/mct - updated : 25-02-2016
HGNC name sphingosine-1-phosphate receptor 4
HGNC id 3170
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane domains 7TM
  • glutamic acid in the third transmembrane domain of the S1P receptors is a general selectivity switch regulating response to S1P over the closely related phospholipids, LPA
    • HOMOLOGY
    interspecies homolog to murine Edg6
    ortholog to Drosophila Mbf1
    ortholog to C.elegans H21p03.1
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • lysophospholipid/lysosphingolipid receptor family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • activating phospholipase C
  • endothelial differentiation, receptor putative lysophospho or lysosphingolipids
  • regulating lymphocyte cell signaling
  • increasing cytolosic calcium ion concentration
  • is involved in shaping the terminal differentiation of megakaryocytes
  • important role for S1PR4 and SPHK1 in oestrogen receptor-negative breast cancer progression
  • is required for plasmacytoid dendritic cell differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • S1PR4 agonists block human Plasmacytoid dendritic cells (pDCs) activation and may therefore be a promising tool to restrict pathogenic IFNA production
    • cell & other
  • lipid and lipid-derived ligands
    • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS