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FLASH GENE
Symbol TPST1 contributors: mct - updated : 03-12-2011
HGNC name tyrosylprotein sulfotransferase 1
HGNC id 12020
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N and C-terminal flanking residues,
  • a transmembrane domain act in targeting and retention of the enzyme to the trans-Golgi compartment
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane glycoproteins
    basic FUNCTION
  • catalyzing tyrosine o-sulfation of proteins
  • acting in targeting and retention of the enzyme to the trans-Golgi compartment
  • transfer the sulfate moiety to proteins predominantly designated for secretion
  • may be functional as homodimer/oligomer in the trans-Golgi compartment
  • involved in photoreceptor outer segment morphogenesis, retinal function and retinal anatomy
  • tyrosine O-sulfation is a post-translational modification catalyzed by two tyrosylprotein sulfotransferases (TPST1 and TPST2) in the trans-Golgi network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in shear stress involves tyrosine kinase (Goettsch 2002)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS