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FLASH GENE
Symbol MAGI1 contributors: mct - updated : 21-01-2011
HGNC name membrane associated guanylate kinase, WW and PDZ domain containing 1
HGNC id 946
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal guanylate-kinase GUK domain
  • two WW (phosphoserine- or phosphothreonine binding) domains, first WW domain responsible for binding to AMOTL2
  • five PDZ domains (PSD95/disc large/ZO-1)
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to C.elegans K01A6.1
    homolog to drosophila Magi
    ortholog to murine Baiap1
    intraspecies paralog to synaptic scaffolding molecule,post synaptic density
    Homologene
    FAMILY MAGUK (membrane-associated guanylase kinase homolog) family
    CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text colocalizing with TJP1
    basic FUNCTION
  • required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion
  • MAGI1 cleavage appears to be an important step in the disassembly of cell-cell contacts during apoptosis
  • may play a role as scaffolding protein at cell-cell junctions
  • has the ability to replace harmonin PDZ2 binding at CDH23 C terminus
  • role in the tip-link complex, where it could provide a sturdy connection with the cytoskeleton and with other components of the mechanoelectrical transduction complex
  • scaffolding protein that allows formation of complexes between certain transmembrane proteins, actin-binding proteins, and other regulatory proteins
  • plays a role in regulation of surface expression of KCNMA1 channels in the kidney and possibly in other tissues
  • scaffolding protein implicated in the stabilization of adherens junctions
  • tumor-suppressor protein induced by PTGS2 inhibitors in colorectal cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • BAI1, cytoplasmic protein
  • NET1 (ligand for the first PDZ domain of BAIAP1)
  • ZCCHC14
  • interacting with IGSF5
  • binds via its PDZ4 domain to a C-terminal PDZ-binding site on CDH23
  • interacting with SDK1, interaction mediated through a direct interaction between the C-terminus of SDK1 and specific PDZ domains of MAGI1
  • substrate of PTPRZ1, with GIT1, and GTPase-activating protein for Rho GTPase (ARHGAP35)
  • MAGI1, -2, and -3 all contain WW domains and were confirmed as PRRG4-binding proteins
  • cell & other
    REGULATION
    Other efficiently cleaved into 97 kDa and 68 kDa fragments by caspases-3 and -7 at physiological concentrations
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia (Kuang 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS