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FLASH GENE
Symbol ITPKA contributors: mct - updated : 16-04-2014
HGNC name inositol 1,4,5-trisphosphate 3-kinase A
HGNC id 6178
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus is a critical region for direct binding to tubulin in dendritic shaft of hippocampal neurons
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY inositol phosphokinase (IPK) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • regulating inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4
  • may be related to carcinogenesis by the modulation of inositol polyphosphates and Ca2+ homeostasis
  • morphological changes induced by ITPKA are mediated by non-enzymatic activities of the protein
  • F-actin binding activity of ITPKA stabilizes and bundles actin filaments and thus increases the levels of cellular F-actin
  • accumulates in dendritic spines and seems to be critically involved in synaptic plasticity
  • dual role in developing neurons, has a morphogenic effect on dendrites, while it appears to play a key role in shaping Ca(2+) transients at mature synapses
  • playing a potential role as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals
  • modulates a structural reorganization of dendritic spines through F-actin remodeling
  • possible function of ITPKA, ITPKB in differentiation of embryonic stem cells
  • expression of ITPKA is essential for lung cancer metastasis
  • actin binding protein essential for metastasis of lung cancer cells and its expression is up-regulated in tumor samples from lung cancer patients
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • forms homodimers and binds actin filaments by its N-terminal domain (AA 1–52), leading to bundling of actin filaments
  • functions as a scaffold for synaptic RAC1 signaling
    • cell & other
    REGULATION
    activated by calmodulin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    ectopic expression in lung cancer cells increases their metastatic potential because the protein exhibits two actin regulating activities
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    inhibitors against the actin bundling activity of ITPKA to effectively inhibit the stimulating effect of ITPKA on metastasis of lung cancer
    cancerlung 
    may be a promising therapeutic molecular target for anti metastatic therapy of lung cancer
    cancermetastases 
    potential targets of anti-metastatic therapy
    ANIMAL & CELL MODELS