Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | PCK2 | contributors: mct - updated : 09-11-2014 |
HGNC name | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
HGNC id | 8725 |
|
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
|
HOMOLOGY |
interspecies | homolog to murine Pck2 |
homolog to C.elegans r11a5.4 |
Homologene |
FAMILY | phosphoenolpyruvate carboxykinase (GTP) family |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,organelle,mitochondria,matrix |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism | carbohydrate |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule | metal binding, nucleotide, |
|
protein |
cell & other |
REGULATION |
activated by | ER stress triggers suppression of AMPK while increasing CEBPB and CREB1 expression which activates PCK2 gene transcription |
induced by | glucagon |
repressed by | insulin | |
ZNF692 (represses gene expression of PCK2, a key enzyme of gluconeogenesis |
Other | regulation of gene expression in the liver by KLF15 |
ASSOCIATED DISORDERS |
corresponding disease(s) | PCK2D |
related resource | MITOP database |
Other morbid association(s) |
|
Susceptibility |
Variant & Polymorphism
| |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |