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FLASH GENE
Symbol AQP7 contributors: mct/npt - updated : 29-09-2007
HGNC name aquaporin 7
HGNC id 640
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane segments (6TM)
  • intracellular N and C termini
  • HOMOLOGY
    Homologene
    FAMILY
  • MIP family
  • aquaglyceroporin family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • aquaglyceroporins, that transport glycerol
  • and small solutes in addition to water (Sorani 2008)
  • water channel forming integral protein
  • putatively involved in the formation of late spermatids
  • may be responsible for the increase of plasma glycerol during exercise, and for glycerol permeability and other small solutes
  • acting as a glycerol gateway molecule in adipocytes for the efficient release of glycerol and protecting against obesity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by insulin via insulin response element of the promoter
    Other adipose tissue expression is regulated by fasting-refeeding, insulin, dexamethasone, TNF, isoproterenol, and peroxisome proliferator-activated receptor PPARA, PPARG
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in severely obese women
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target aquaporins appear to be important for the development of novel drug therapies for Meniere's disease and related disorders (Takeda 2009)
    ANIMAL & CELL MODELS
    Aqp7 disruption in mouse associated with obesity