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FLASH GENE
Symbol HIST3H3 contributors: mct - updated : 08-09-2010
HGNC name histone cluster 3, H3
HGNC id 4778
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated Other
mono polymer octamer
HOMOLOGY
Homologene
FAMILY
  • histone H3 family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text incorporated into the chromatin in the early stage of spermatogenesis (Tachiwana 2010)
    basic FUNCTION
  • dynamic changes in chromatin structure through post-translational modifications of HIST3H3 during replication origin activation (Rampakakis 2009)
  • playing a role in the compaction of DNA into nucleosomes
  • may be assembled into the chromatin by a specific chaperone-mediated pathway in the testis (Tachiwana 2010)
  • prominent property of the H3T nucleosome is its instability (Tachiwana 2010)
  • may have a specific function in chromatin reorganization during meiosis and/or the postmeiotic maturation of male germ cells (Tachiwana 2010)
  • specific biochemical and structural properties of the H3T nucleosome, like those containing the H2B variants, could also play an important epigenetic role in the regulation of genes containing nucleosomes in the sperm (Tachiwana 2010)
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • core histone H2A/H2B/H3/H4
  • INTERACTION
    DNA binding approximatively 0.146 kb
    RNA
    small molecule
    protein
  • H2A, H2B, H3, H4
  • H3K4me3, through interactions with TAF3, directs global TBP recruitment
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS