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FLASH GENE
Symbol PAPSS2 contributors: npt/mct - updated : 10-10-2016
HGNC name 3'-phosphoadenosine 5'-phosphosulfate synthase 2
HGNC id 8604
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to PAPSS1 (77 p100)
Homologene
FAMILY
  • sulfate adenyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • PAPSS1 was predominantly nuclear, whereas PAPSS2 localised mainly within the cytoplasm
  • basic FUNCTION
  • catalyzing the activation of sulfate in two steps, synthesis of adenosine 5'-phosphosulfate and phosphorylation of APS to generate 3'-phospho-adenosine 5'-phosphosulfate (PAPS)
  • may have a important role in skeletogenesis during postnatal growth
  • may be having a important role of the gene product for cartilage growth and development
  • might regulate osteoblast alkaline phosphates activity and cell mineralization, probably through Smads signal pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS locomotion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coexpressed with PAPSS1
  • enhanced PAPSS2/VCAN sulfation axis is essential for SNAI1-mediated breast cancer cell migration and metastasis
  • cell & other
    REGULATION
    induced by during chondrogenesis
    Other regulated by extracellular signal-regulated protein kinase, protein kinase C, and p38 kinase, signaling molecules known to regulate chondrogenesis
    ASSOCIATED DISORDERS
    corresponding disease(s) SEMD4 , BCYM4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    PAPSS2 deficiency is a monogenic adrenocortical cause of androgen excess
    constitutional       loss of function
    causes androgen excess via impaired DHEA sulfation, and is associated with a phenotype resembling polycystic ovary syndrome
    Susceptibility to osteoarthritis(minor role in japanese)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS