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FLASH GENE
Symbol NDUFA8 contributors: mct - updated : 22-08-2011
HGNC name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
HGNC id 7692
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a motif of eight cysteine residues
  • two twin Cx9C domains
  • a hydrophobic motif at the N terminus, suggesting that the protein is incorporated in the mitochondrial inner membrane
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    text with NDUFB, located at the intermembrane surface of complex I, and stabilize the membrane domain of complex I
    basic FUNCTION may play an important role in mitochondrial function
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component alpha 8, hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
    INTERACTION
    DNA
    RNA
    small molecule
    protein NDUFA8 forms intramolecular disulfide bridges and, together with NDUFB7, is localized in the mitochondrial inter membrane space
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS