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FLASH GENE
Symbol ENC1 contributors: - updated : 17-03-2006
HGNC name ectodermal-neural cortex (with BTB-like domain)
HGNC id 3345
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal BTB/POZ domain-like structure and
  • a C terminal 6 Drosophila Kelch motifs (tandemly arranged repeats)
  • a intervening sequence (IVS) domain
  • HOMOLOGY
    Homologene
    FAMILY BTB/Kelch repeat family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • involved in differentiation of neural crest cells
  • F-actin associated protein involved in differentiation of neural crest, colon and adipocyte cells
  • may contribute to brain tumorigenesis by promoting cell proliferation, suppressing apoptosis and by affecting nuclear cytoskeleton dynamics
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component constituent of nuclear matrix protein
    INTERACTION
    DNA
    RNA
    small molecule
    protein associating with RB1
    cell & other
    REGULATION
    Other regulated by the CTNNB/TCF pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in brain tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS