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FLASH GENE
Symbol EIF3A contributors: mct - updated : 21-12-2016
HGNC name eukaryotic translation initiation factor 3, subunit A
HGNC id 3271
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 21 units of an anusual 10 AA repeat
  • a PCI (PINT) proteasome Int-6,Nip-1, Trip-1 motif
  • HOMOLOGY
    interspecies homolog to murine centrosomin B
    Homologene
    FAMILY
  • eukaryotic translation initiation factor family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    text
  • expression oscillated with cell cycle and peaked in S phase
  • basic FUNCTION
  • role in translation initiation, possibly by acting as an adapter molecule between the translation initiation apparatus and the cytoskeleton structure in the cell
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • may play some roles in development and differentiation and decreased EIF3A expression may be a pre-requisite of intestinal epithelial cell differentiation
  • participating in the initiation process of translation
  • EIF3A-PAIP1 stabilizes the interaction between PABP and EIF4G, which brings about the circularization of the mRNA
  • play an important role in cellular responses to external cell cycle modulators likely by affecting synthesis of target proteins of these modulators
  • may play a role as a regulator of a subset of mRNAs and has been demonstrated to regulate the expression of CDKN1B, tyrosinated alpha-tubulin and ribonucleotide reductase M2 subunit
  • CELLULAR PROCESS nucleotide, transcription, initiation
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text protein synthesis factor
    PATHWAY
    metabolism
    signaling
    a component
  • component of 800 kDa molecular mass assembly of 13 proteins (EIF3A-EIF3M)
  • INTERACTION
    DNA
    RNA binding to the 40S ribosomal subunit
    small molecule
    protein
  • binding to intermediate filament protein K7 (cytokeratin 7)
  • binding to EIF3B
  • SLBP can interact directly with subunit h of EIF3A and with PAIP1
  • interaction with PAIP1 stabilizes the interaction between PABPC1 and EIF4G, which brings about the circularization of the mRNA
  • PAIP1 act as a translational activator in 5 prime cap-dependent translation by interacting with PABPC1 and the initiation factors EIF4A1 and EIF3A
  • dimer of subunits EIF3A and EIF3C serves as a central scaffold to which most of the other subunits bind
  • RPS6KB1/2 phosphorylate EIF3A to stimulate PAIP1-EIF3A interaction and consequent translation initiation
  • neuron-specific ARHGEF9 interacts with EIF3A, and its binding partner GPHN associates with MTOR
  • EIF4G2 and EIF4G1 share many binding proteins, such as the eukaryotic translation initiation factors EIF3A and EIF4A1 and ribosomal proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in breast, cervical, esophageal and stomach carcicomas
    tumoral     --over  
    P150 activated in several cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS