Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EIF6 contributors: mct - updated : 01-02-2015
HGNC name eukaryotic translation initiation factor 6
HGNC id 6159
PROTEIN
PHYSICAL PROPERTIES fibrous
STRUCTURE
motifs/domains
  • prokaryotic membrane lipoprotein lipid attachment site
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Itgb4bp (98.8 pc)
    homolog to murine Itgb4bd (98 pc)
    Homologene
    FAMILY
  • eIF-6 family
  • CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus,nucleolus
    text
  • associated with the intermediate filament cytoskeleton
  • in the nucleolus, EIF6 is a component of the pre-ribosomal particles and is required for the biogenesis of 60S subunits, whereas in the cytoplasm it mediates translation downstream from growth factors
  • basic FUNCTION
  • acting as a translation initiation factor
  • linking ITGB4 to intermediate filament cytoskeleton
  • preventing association of the 60S ribosomal subunit with the 40S ribosomal subunit to form the 80S initiation complex
  • is the first EIF associated with the large 60S subunit that regulates translation in response to extracellular signals
  • necessary protein with a unique anti-association activity, which prevents the interaction of 40S ribosomal subunits with 60S subunits through its binding to 60S ribosomes
  • necessary for tissue-specific growth and oncogene-driven transformation, and could be a new rate-limiting step for the initiation of translation
  • removal of the assembly factor eukaryotic initiation factor 6 (EIF6) is critical for late cytoplasmic maturation of 60S ribosomal subunits
  • controls translation by regulating 80S subunit formation
  • rate-limiting controller of initiation of translation, able to affect tumorigenesis and tumor growth
  • is a ribosome anti-association factor that has been implicated in translational initiation and in ribosome synthesis
  • CELLULAR PROCESS protein, translation regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bindign to the fibronectin type III domains of ITGB4
  • SBDS and the GTPase elongation factor-like 1 (EFL1) directly catalyze EIF6 removal in mammalian cells by a mechanism that requires GTP binding and hydrolysis by EFL1 but not phosphorylation of EIF6 Ser 235
  • is one of the downstream effectors of NOTCH1 in the pathway that controls cell motility and invasiveness
  • cell & other
  • binding to the 60S ribosomal subunit
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal tumor (transition from benign to malignant tumor)
    tumoral     --over  
    in head and neck carcinomas and their lymph node metastases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    Modulation of eIF6 activity, independent from EIF4F complex, may lead to a therapeutical avenue in tumor therapy
    ANIMAL & CELL MODELS
  • eIF6(+/-) mice resist to Myc-induced lymphomagenesis and have prolonged tumor-free survival and reduced tumor growth, and are also protected by Tp53 loss