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FLASH GENE
Symbol ANKRD17 contributors: mct/npt - updated : 22-06-2009
HGNC name ankyrin repeat domain 17
HGNC id 23575
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two clusters of a total 25 ankyrin repeats at its N terminus
  • one NES (nuclear exporting signal)
  • one NLS (nuclear localization signal) in the middle
  • one RXL motif at its C terminus
  • HOMOLOGY
    interspecies ortholog to murine Gtar
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text localized to the nucleus (Deng 2009)
    basic FUNCTION
  • may be directly involved in the DNA replication process
  • is an important downstream effector of cyclin E/CDK2 and positively regulates G1/S transition (Deng 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with DNA replication factors including MCM family members, CDC6 and PCNA (Deng 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS