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FLASH GENE
Symbol DNAJC13 contributors: mct - updated : 08-11-2017
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 13
HGNC id 30343
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal conserved J domain through which they form a complex with heat shock cognate 70 (HPA8), enhancing the chaperone ATPase activity
  • HOMOLOGY
    interspecies homolog to C.elegans cosmid F18C12
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • localization of DNAJC13 to endosomal compartments is spatially mediated by PI(3)P binding and temporally regulated by MTMR2 activity
  • basic FUNCTION
  • involved in amino acid activation
  • peripheral protein that was tightly associated with the membrane via its N-terminal region
  • is primarily involved in membrane trafficking through early endosomes, but not through degradative organelles, such as multivesicular bodies and late endosomes
  • acting as a tRNA ligase
  • regulates the cellular levels of EGFR by contributing to the control of EGFR endosomal trafficking and degradation, regulating membrane trafficking through early endosomes
  • could have a general influence on the trafficking of receptors that are targeted via ubiquitination to the degradative pathway
  • regulates the dynamics of clathrin coats on early endosomes
  • DNAJ domain containing protein implicated in translocation of HSPA8 to early endosomes for clathrin removal during retrograde transport
  • is a co-chaperone on endosomes and may have a role in clathrin-coated vesicle endocytosis on this organelle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • potential regulatory target in ERBB2-positive breast cancers
  • interaction between DNAJC13 and the WASH complex provides a means to coordinate the activity of the WASH complex with the membrane-tubulating function of the sorting nexins at sites where retromer-mediated endosomal protein sorting occurs
  • critical role for PI(3)P in theDNAJC13-mediated organizational control of various endosomal activities, including retrograde transport
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PARK21
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS