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FLASH GENE
Symbol MVK contributors: mct - updated : 20-06-2017
HGNC name mevalonate kinase (mevalonic aciduria)
HGNC id 7530
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N terminal putative ATP binding aminoacid sequence
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Mvk
Homologene
FAMILY GHMP kinase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
text
basic FUNCTION
  • catalyzing an early step in the mevalonate pathway (conversion of murelonate into 5-phosphomevalonate) for the synthesis of isoprenoids and cholesterol
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
  • a structural constituent of membranes and precursor for bile acids and steroid hormones
  • homodimeric enzyme
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MVK is a LH receptor mRNA binding protein regulating LH receptor activity in ovary
  • binds to the coding region of LHCGR mRNA, suppresses its translation, and the resulting ribonucleoprotein complex is targeted for degradation
  • by inhibiting EIF5A hypusination, FSH reduces the expression of MVK that increases LHCGR mRNA expression by abrogating the inhibitory action of MVK
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MVKD , HIDS , POROK3
    related resource INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS