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FLASH GENE
Symbol DAAM1 contributors: mct/pgu - updated : 31-08-2016
HGNC name dishevelled associated activator of morphogenesis 1
HGNC id 18142
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal GTPase binding domain (GBD) that encompasses the diaphanous inhibitory domain (DID)
  • FH1 domain
  • formin-homology-2 (FH2) domain
  • C-terminal diaphanous autoregulatory domain (DAD), and binding partner, DVL, that leads to the activation of DAAM1, and selectively inhibited endothelial cell proliferation
  • HOMOLOGY
    interspecies homolog to diaphanous
    Homologene
    FAMILY
  • FH protein subfamily implicated in cell polarity
  • formin protein family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • central player in mediating cytoskeletal reorganization and are epistatically positioned in a pathway downstream of Rho activation
  • directing nucleation and elongation of new actin filaments using its conserved formin-homology-2 (FH2) domain
  • DIAPH1 and DAAM1 are platelet actin assembly factors having distinct efficiencies, and they are directly regulated by Rho GTPases
  • regulates endothelial cell growth through microtubules stabilization in a cell type-selective manner
  • may be playing an unique role in endothelial cells not shared with other similar cell types
  • plays a key role in centrosome polarity
  • plays an important role in regulating the actin cytoskeleton via mediation of linear actin assembly
  • crucial role in regulating the actin cytoskeleton and tissue morphogenesis, and in heart morphogenesis
  • participates in noncanonical Wnt signaling during gastrulation
  • DIAPH2, DAAM1, FMNL1, and FMNL2 were found to be required for myofibrillogenesis, non-redundantly
  • DAAM1 and DAAM2 nucleate actin and mediate Wnt-induced cytoskeletal changes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to both DVL and Rho, and mediates Wnt-induced DVL-Rho complex formation
  • coexpression of DVL with DAAM1 leads to activation of DAAM1 as monitored by hyperactivation of the noncanonical WNT pathway
  • FLI1, a gelsolin family protein essential for early development, binds directly to DAAM1 and DIAPH1 (FLI1 enhances the intrinsic actin assembly activity of DAAM1 and DIAPH1 and is required for DAAM1-induced actin assembly in living cells)
  • DAAM1 likely has WNT5A-independent roles in cardiac development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Daam1-deficient mice exhibit embryonic and neonatal lethality and suffer multiple cardiac defects, including ventricular noncompaction, double outlet right ventricles and ventricular septal defects
  • homozygous Daam1 conditional knockout (CKO) mice were viable but had misshapen hearts and poor cardiac function