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FLASH GENE
Symbol SH3BP4 contributors: mct - updated : 20-10-2017
HGNC name SH3-domain binding protein 4
HGNC id 10826
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal SH3 domain
  • three EH binding sites
  • the consensus N-P-Z aspargine-proline-phenylalanine motif
  • a PXXP motif between NPZ2
  • in the C terminal region a bipartite nuclear localization signal (NLS)
  • a Tyr phosphorylation site
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    intracellular,nuclear envelope
    text
  • compared to other EPS15 homolog network and death domain proteins, SH3BP4 fusion proteins have an unusual intracellular localization to the plasma membrane and the nuclear periphery
  • basic FUNCTION
  • maybe involved in a newly cascade of proteins involved in endocytosis intracellular sorting and the cell cycle
  • has likely physiological significance for retinal pigment epithelial (RPE) cells
  • is a key molecule for selective internalization of the transferrin receptor (Tf-R) through endocytic protein complexes
  • is a negative regulator of the Rag GTPase complex and amino acid-dependent MTOR signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SH3 binding
  • SH3-containing protein, specifically regulates the internalization of the transferrin receptor (TfR)
  • directly binds to multiple 14-3-3 isotypes via its Ser(245) residue (Ser246) and these proteins are associated at the plasma membrane
  • recently identifed as a negative regulator of Rag GTPases (RRAGA, RRAGB, RRAGC, RRAGD)
  • cell & other
    REGULATION
    Other is transcriptionally regulated by microphthalmia-associated transcription factor as its direct target
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS