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FLASH GENE
Symbol PHLDB1 contributors: mct - updated : 10-12-2015
HGNC name pleckstrin homology-like domain, family B, member 1
HGNC id 23697
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a forkhead associated (FHA) domain
  • a bipartite nuclear localization signal (NLS)
  • chromosome segregation ATPases (SMC) domain
  • a pleckstrin homology (PH) domain
  • HOMOLOGY
    interspecies homolog to rattus LL5 protein
    intraspecies homolog to PHLDB2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be a transducer of PtdIns (3,4,5)P3 levels to the intracellular trafficking system
  • PHLDB1 and PHLDB2 are required, together with PPFIA1, for effective migration and tumor cell invasion, and do so by stabilizing the protrusive activity at the cell front
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Glioblastoma (GBM)
    Variant & Polymorphism significant association between variant TT genotype of PHLDB1 rs498872 and GBM development
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS