Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol POM121 contributors: mct - updated : 29-05- 201
HGNC name POM121 membrane glycoprotein (rat)
HGNC id 19702
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nuclear localization signals, which bind to importin beta via importin alpha and likely function with RANGTP, play an essential role in targeting POM121 to the interphase nuclear pore complex
  • HOMOLOGY
    interspecies homolog to rattus nuclear envelope pore membrane protein POM121,homolog-related
    Homologene
    FAMILY
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope,pore
    text
  • present at new pore assembly sites at a time that coincides with inner nuclear membrane (INM) and outer nuclear membrane (ONM) fusion
  • basic FUNCTION
  • playing a role on maintenance of nuclear pore complex structure/organization
  • vertebrate-specific integral membrane nucleoporin, is indispensable for an early step in interphase nuclear pore complex assembly
  • nuclear migration of POM121 and its subsequent interaction with INM (inner nuclear membrane) proteins are required to initiate interphase NPC assembly
  • SUN1 specifically required for interphase assembly and localized with POM121 at forming pores
  • plays an important role in both modes of assembly and links nuclear membrane formation and expansion to nuclear pore biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component components of the nuclear pore complex (NPC) in vertebrate
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • capture of AT-rich chromatin by AHCTF1 recruits POM121 and NDC1 to initiate nuclear pore assembly
  • interacts with importin alpha/beta and a group of nucleoporins in an NLS-dependent manner
  • N terminus of POM121 directly binds the beta-propeller regions of NUP155 and NUP160
  • POM121 and SUN1 interact transiently to promote early steps of interphase Nuclear pore complexes assembly
  • NPAP1, originating from the vertebrate nucleoporin gene POM121 and--after several steps of retrotransposition and duplication-has been subjected to genomic imprinting and positive selection after integration into the imprinted SNRPN-UBE3A chromosomal domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS