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FLASH GENE
Symbol XPO6 contributors: mct - updated : 19-11-2011
HGNC name exportin 6
HGNC id 19733
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an importin N-terminal domain
HOMOLOGY
Homologene
FAMILY exportin family
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleolus
intracellular,nuclear envelope,pore
basic FUNCTION
  • recruit cargo in the nucleoplasm in the presence of RAN-GTP and form ternary export complexes
  • mediates nuclear export of profilin-actin complexes
  • first example of a strictly developmentally regulated nuclear transport pathway
  • reduction of its activity leads to actin accumulation via failure of RANGTP restoration and NUTF2 sequestration in the nuclei of senescent cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other reduction of exportin 6 activity leads to actin accumulation, in nuclei that is a universal phenomenon of cellular senescence
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    significantly reduced in the replicative senescence
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS