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FLASH GENE
Symbol DIDO1 contributors: mct - updated : 06-12-2014
HGNC name death inducer-obliterator 1
HGNC id 2680
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal plant homeo domain (PHD) (residues 74134), contributing to chromatin association by binding trimethylated H3K4 peptides
  • a zinc finger motif
  • two nuclear localization signals (NLS)
  • transcriptional activation domain
  • central TFIIS-like domain (TLD, residues 232365), important for the association with chromatin
  • C-terminal Spen paralogue and orthologue C-terminal (SPOC) domain (residues 447547), implicated in developmental signaling
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Datf (76.4 pc)
    homolog to murine Dido (75.9 pc)
    homolog to yeast Bye1
    intraspecies homolog to KIAA0244
    Homologene
    FAMILY
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • translocated to the nucleus after pro-apoptotic stimuli
  • localizes to the nucleus
  • basic FUNCTION
  • triggering apoptosis
  • involved in regulation of transcription, DNA dependent
  • involved in onset of apoptosis where misexpression disrupts limb development
  • its malfunction is reported to be part of an impaired signaling cascade that results in a defective mitotic checkpoint, leading to chromosome instability
  • induces the expression of ITGA5, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells
  • is the founding member of a unique family of chromatin transcription factors that link histones with active posttranslational modifications (PTMs) to transcribing Pol II
  • plays an important role in regulating ES cell maintenance.
  • once Pol II is engaged into elongation, PHF3 and DIDO1 binds directly to the transcriptional machinery, modulating its progression along the gene
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • BMP-specific SMAD-regulated target gene
  • binds to early Pol II elongation complexes at the beginning of transcribed regions of active genes without changing polymerase structure or function
  • could target to the loci of pluripotency factors such as NANOG and POU5F1 and positively regulate their expression
  • cell & other
    REGULATION
    inhibited by caspase inhibitors and BCL2 overexpression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    altered expression implicated in the induction of hematological myeloid neoplasms
    tumoral     --over  
    in melanoma cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • targeted disruption causes a transplantable myelodysplastic/myeloproliferative disease in mice (Trachana (07)
  • specific ablation of Dido3 function in mice causes lethal developmental defects at the onset of gastrulation