basic FUNCTION
| triggering apoptosis |
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involved in regulation of transcription, DNA dependent |
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involved in onset of apoptosis where misexpression disrupts limb development |
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its malfunction is reported to be part of an impaired signaling cascade that results in a defective mitotic checkpoint, leading to chromosome instability |
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induces the expression of ITGA5, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells |
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is the founding member of a unique family of chromatin transcription factors that link histones with active posttranslational modifications (PTMs) to transcribing Pol II |
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plays an important role in regulating ES cell maintenance. |
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once Pol II is engaged into elongation, PHF3 and DIDO1 binds directly to the transcriptional machinery, modulating its progression along the gene |