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FLASH GENE
Symbol ZFYVE26 contributors: shn - updated : 03-01-2014
HGNC name zinc finger, FYVE domain containing 26
HGNC id 20761
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one FYVE-type zinc finger domain
  • a putative zinc finger C2H2 and leucine zipper domains
  • predicted to have secondary structures containing alpha-solenoids
  • HOMOLOGY
    interspecies ortholog to Zfyve26, Mus musculus
    ortholog to Zfyve26, Rattus norvegicus
    ortholog to ZFYVE26, Pan troglodytes
    ortholog to zfyve26, Danio rerio
    Homologene
    FAMILY
  • FYVE-finger family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • localizes to the endosomal membrane traffic compartment, suggesting that the long axons of the corticospinal tract may be especially vulnerable to endosomal dysfunction
  • localizes on a late endosomal/lysosomal compartments
  • broadly expressed in neurons, associates with intracellular vesicles immunopositive for the early endosomal marker EEA1, and co-fractionates with a component of the AP5 complex
  • basic FUNCTION
  • may be playing a role in intracellular trafficking
  • involved in the abscission step during cytokinesis
  • important for proper development of the axons of spinal motor neurons
  • role in autophagy and required for autophagosome maturation
  • involved in the endolysosomal system
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS nervous system , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • microtubule motor KIF13A and tetratricopeptide repeat domain 19, TTC19
  • KIAA0415
  • AP-5 subunits
  • Beclin 1, Vps34, Rubicon and UVRAG
  • cell & other phosphatidylinositol-3-phosphate (PtdIns(3)P)
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG15
    Susceptibility
  • atypical juvenile parkinsonism
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • SPG15 knock-down in zebrafish by morpholino antisense oligonucleotides lead to locomotor impairment and abnormal branching of spinal cord motor neurons at the neuromuscular junction
  • SPG15 knockdown causes the cation-independent mannose 6-phosphate receptor to become trapped in clusters of early endosomes as well as the tubulation of EEA1-positive endosomesof HeLa cellof HeLa cells
  • autophagy defects with autophagosome accumulation is observed also in neuronal cells upon spastizin silencing
  • Zfyve26 knockout mice develop late-onset spastic paraplegia with cerebellar ataxia, display axon degeneration and progressive loss of both cortical motoneurons and Purkinje cells in the cerebellum
  • an increase of Lamp1-positive membrane compartments with higher densities in Zfyve26 knockout mice