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FLASH GENE
Symbol ZFYVE16 contributors: mct/npt - updated : 05-06-2019
HGNC name zinc finger, FYVE domain containing 16
HGNC id 20756
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • FYVE zinc finger
  • a protein-phosphatase-binding motif, which functions to negatively modulate BMP signals through receptor dephosphorylation
  • C-terminal half is responsible for interaction with the C-terminal region of TOM1 and for recruitment of TOM1 and clathrin to endosomes
  • HOMOLOGY
    interspecies homolog to C.elegans cosmid D1022
    intraspecies homolog to SARA1
    Homologene
    FAMILY FYVE-domain protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a potential roles in regulating membrane traffic
  • facilitates TGF- signaling as a scaffold protein to promote the R-Smad-Smad4 complex formation by bringing SMAD4 to the proximity of the receptor complex
  • plays an important role in both positive and negative feedback regulation of the BMP signaling pathway, acting a SMAD anchor for receptor activation in BMP signaling
  • plays an important role in both positive and negative feedback regulation of the BMP signaling pathway (Shi 2007)
  • endosome-associated FYVE-domain protein endofin which acts as a Smad anchor for receptor activation in BMP signaling (Shi 2007)
  • possible role of Endofin in the modulation of MAPK pathway
  • is involved in endosomal trafficking and in TGFB1, BMP, and EGFR signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targeted to early endosomes by its FYVE domain and colocalized with SARA1
  • interacting with TOM1
  • modulates hepcidin through BMP-SMAD signalling
  • ZFYVE16 binds to SMAD4 and their binding affects the formation of SMAD2/3-SMAD4 complex in TGFB1 signaling
  • ZFYVE9, ZFYVE16 recruit the tumor supressor PTPN23, a master regulator of endosomal sorting and ESCRT-dependent receptor downregulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS