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FLASH GENE
Symbol ARHGEF10 contributors: mct/npt - updated : 06-09-2017
HGNC name Rho guanine nucleotide exchange factor (GEF) 10
HGNC id 14103
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tandem DBL homology-pleckstrin homology
  • putative transmembrane domains
  • a putative WD40-like domain
  • HOMOLOGY
    intraspecies homolog to ABR protein 2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • stimulating guanine nucleotide exchange for Rac and Rho
  • third member of a Rho-specific GEF family with unusual protein architecture (Mohl 2006)
  • specifically activated RHOA, which has an important role in various process of atherosclerosis (Matsushita 2010)
  • specifically activated RhoA and might contribute to the development of atherothrombotic stroke through the regulation of RhoA–Rho kinase activity (Matsushita 2010)
  • with ARHGEF10, ARHGEF2, ARHGEF12, PLEKHG1 and ARHGEF28, are involved in cyclic-stretch-induced perpendicular reorientation of endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • kinesin-like motor protein KIF3B is a binding partner of ARHGEF10 (kinesin-like motor protein KIF3B may modulate the ARHGEF10-RhoA pathway through the binding to ARHGEF10)(Aoki 2009)
  • RhoA is a substrate for ARHGEF10 (novel RhoA-dependent signaling pathway under the control of ARHGEF10 has a pivotal role in the regulation of the cell division cycle) (Aoki 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ischemic stroke
    Variant & Polymorphism SNP rs4376531 CC or CG increase the incidence of ischemic stroke (Matsushita 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS