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FLASH GENE
Symbol WWP2 contributors: mct - updated : 22-08-2013
HGNC name WW domain containing E3 ubiquitin protein ligase 2
HGNC id 16804
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C2 domain
  • four WW (phosphoserine- or phosphothreonine binding) domains
  • a C terminal HECT domains (conserved cysteine characteristic of E3 ubiquitin ligase)
  • HOMOLOGY
    Homologene
    FAMILY NEDD4-like protein family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • ubiquitin-protein ligase activity
  • important regulator of the POU5F1 protein level in human embryonic stem cells
  • crucial role in controlling endogenous POU5F1 protein levels during differentiation processes of embryonal carcinoma cells
  • involved in regulating transcription, embryonic stem-cell fate, cellular transport and T-cell activation processes
  • functional E3 ubiquitin ligase for PTEN that plays a vital role in tumour-cell survival
  • developmental role for WWP2 in chondrogenesis via mechanisms involving cartilage-specific transcription factors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ubiquitin ligase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • atrophin 1 binding
  • ZCCHC14
  • influences craniofacial patterning through its interactions with Goosecoid (GSC), a paired-like homeobox transcription factor that has an important role in craniofacial development
  • interacts exclusively with SMAD2, SMAD3 and SMAD7 in the TGFB pathway
  • direct target of SOX9 (interacts physically with SOX9 and is associated with SOX9 transcriptional activity via its nuclear translocation)
  • regulatory interaction between SOX9, WWP2 and MED25 defines the SOX9 transcriptional mechanisms of chondrogenesis in the forming palate
  • physically interacts with PTEN and mediates its degradation through a ubiquitylation-dependent pathway
  • plays a negative role by binding to ADARB1 and catalysing its ubiquitination and subsequent degradation
  • WWP2 mediated K48-linked ubiquitination and degradation of TICAM1 upon TLR3 activation
  • WWP2, an E3 ligase, is a novel TP73-associated protein that ubiquitinates and degrades TP73
  • phosphatase PPM1G is a functional switch that controls the balance between monomeric WWP2 and a WWP2/WWP1 heterodimeric state in the cell
  • WWP2, a homolog of the HECT-type ubiquitin ligase WWP1, interacts with and targets PAIP1 for ubiquitination and proteasomal degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mice deficient in Wwp2 develop malformations of the craniofacial region