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FLASH GENE
Symbol FDX1 contributors: mct - updated : 20-11-2017
HGNC name ferredoxin 1
HGNC id 3638
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 2fe-2s ferredoxin-type domain
  • HOMOLOGY
    Homologene
    FAMILY
  • adrenodoxin/putidaredoxin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,nucleus
    text
  • present in the matrix of human mitochondria
  • basic FUNCTION
  • small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to a terminal cytochrome P450
  • mitochondrial electron transfer protein, is able to support reactions catalyzed by human microsomal P450 (Pechurskaya 2007)
  • participating in the synthesis of thyroid hormones
  • able to reduce mitochondrial cytochrome P450 (Sheftel 2010)
  • can only reduce mitochondrial CYP enzymes that are essential in adrenal steroidogenesis, bile acid formation, and vitamin D synthesis (Sheftel 2010)
  • is an iron-sulfur protein that is involved in various metabolic processes, including steroid hormone synthesis in mammalian tissues
  • transcription of FDX1 is regulated by the NR5A family and cAMP signaling, and participates in steroid hormone production in ovarian granulosa cells
  • TNFSF13 and FDX1 have potential roles in IgA nephropathy (IgAN)
  • FDX1L, FDX1, play an important role as an electron donor in iron-sulfur (Fe-S) cluster biosynthesis
  • FDX1L, FDX1 can function in Fe-S cluster assembly
  • has an only weak effect on ferric and ferrous CO states, but it has a relatively stronger impact on the Fe-O-O fragments of the functionally relevant oxy complexes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds 1 2fe-2s cluster
  • protein
  • interference with any of the three related genes, FDX1, FDX1L or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis
  • NR5A1 could bind to the FDX1 promoter in differentiated hMSCs
  • supports steroid biosynthesis in steroidogenic cells through electron transfer to the rate-limiting steroidogenic enzyme, CYP11A1
  • mitochondrial cytochrome P450s require adrenodoxin (FDX1) and adrenodoxin reductase (FDXR)
  • JUN may cooperate with other partners to regulate FDX1 in Leydig cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS