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FLASH GENE
Symbol CLDN7 contributors: mct - updated : 21-06-2023
HGNC name claudin 7
HGNC id 2049
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four putative transmembrane segments
  • HOMOLOGY
    interspecies homolog to murine Cldn7 (91.9pc)
    Homologene
    FAMILY
  • claudin family
  • CATEGORY adhesion , structural protein , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm
    text
  • CLDN7 colocalized with EPCAM at cell-cell junctions, and the two proteins were found to associate with each other
  • basic FUNCTION
  • playing a major role in tight junction specific obliteration of the intercellular space
  • creating charge specific channels in the paracellular space
  • regulate the integrity and function of tight junctions and influence tumorigenesis
  • with CLDN8, are tight junction proteins expressed in distal nephron epithelium
  • inhibits cell migration and invasion through ERK/MAPK signaling pathway in response to growth factor stimulation in lung cancer cells
  • EPCAM and its associated protein, CLDN7, play a critical role in reprogramming
  • is indispensable in controlling WNT/CTNNB1 signaling-dependent intestinal epithelial stem cell survival, self-renewal, and cell differentiation
  • tumor suppressive function for CLDN7 in a TP53-dependent manner, which may mediate colorectal tumorigenesis induced by TP53 deletion or mutation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major structural components of tight junction (TJ) strands
  • an EPCAM-CLDN7 complex, rather than EPCAM itself, can promote proliferation, apoptosis resistance, migration, and tumorigenicity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TJP1/ZO-1
  • TJP2/ZO-2
  • TJP3/ZO-3
  • induction by ELF3 appears critical to the formation of the epithelial structures in biphasic synovial sarcoma
  • interacted strongly with CLDN3 and CLDN7, normal TJ constituents in the collecting duct
  • EPCAM bound tightly to CLDN7 (CLDN7 was required for association of CLDN1 with EPCAM)
  • HNF4A is a regulatory factor that bound endogenous CLDN7 promoter in differentiating intestinal epithelial cell (IEC) and stimulated CLDN7 promoter activity
  • CLDN7 plays an important role in salt balance in renal collecting duct (CD) cells and modulating WNK4 and SCNN1A expression levels that are vital in controlling salt-sensitive hypertension
  • mechanistically, TP53 could bind to CLDN7 promoter region and regulate its expression
  • TACSTD2 was able to compensate for the loss of EPCAM in stabilizing CLDN7 expression and cell membrane localization in tissues that co-express both proteins
  • cell & other
    REGULATION
    induced by androgens
    TSLP (TSLP induces expression of CLDN7 in dendritic cells (DCs) via NF-kappaB as well as via TLRs and may control tight junctions of DCs to preserve the epithelial barrier during allergic inflammation)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    frequently up-regulated in gastric adenocarcinoma
    tumoral     --other  
    expression tightly associated with epithelial structures in synovial sarcomas
    tumoral     --low  
    might lead to venous invasion and liver metastasis in colorectal cancer, and reduced expression of CLDN7 may thus be a useful predictor of liver metastasis in patients with colorectal cancer
    tumoral     --over  
    negatively correlated with tumor size, invasion depth, lymphatic metastasis and AJCC III/IV stage, but was positively associated with favorable prognosis of Colorectal cancer patients
    tumoral     --over  
    is closely related to lymph node metastasis in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma
  • the expression of CLDN7 and the loss of CLDN18 may be independent indicators of a poor prognosis in patients with gastric cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    may have an indispensable potential for future anti-metastatic and therapeutic applications
    cancerdigestivepancreas
    may be a novel molecular target for the treatment of pancreatic cancer.
    ANIMAL & CELL MODELS
  • Claudin-7 knockout (CLDN7-/-) mice display renal salt wasting and dehydration phenotypes