basic FUNCTION
| playing a major role in tight junction specific obliteration of the intercellular space |
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creating charge specific channels in the paracellular space |
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regulate the integrity and function of tight junctions and influence tumorigenesis |
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with CLDN8, are tight junction proteins expressed in distal nephron epithelium |
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inhibits cell migration and invasion through ERK/MAPK signaling pathway in response to growth factor stimulation in lung cancer cells |
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EPCAM and its associated protein, CLDN7, play a critical role in reprogramming |
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is indispensable in controlling WNT/CTNNB1 signaling-dependent intestinal epithelial stem cell survival, self-renewal, and cell differentiation |
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tumor suppressive function for CLDN7 in a TP53-dependent manner, which may mediate colorectal tumorigenesis induced by TP53 deletion or mutation |