Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PTP4A1 contributors: shn/npt - updated : 28-12-2016
HGNC name protein tyrosine phosphatase type IVA, member 1
HGNC id 9634
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a tyrosine-protein phosphatase domain
  • C-terminal polybasic region important for specific phosphoinositide recognition, with prenylation motif CAAX
  • mono polymer homomer , monomer
    HOMOLOGY
    interspecies ortholog to ptp4a1, Danio rerio
    ortholog to Ptp4a1, Rattus norvegicus
    ortholog to Ptp4a1, Mus musculus
    ortholog to PTP4A1, Pan troglodytes
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    basic FUNCTION
  • immediate early gene in regenerating liver, involved in cellular growth of the liver
  • may play a role in the development and maintenance of differentiating epithelial tissues
  • implicated in promoting cell growth, differentiation, and tumor invasion
  • enhancing cell proliferation, cell motility and invasive activity, and promotes cancer metastasis
  • may be a significant regulator in the development and metastasis of a variety of cancer types
  • may contribute to tumor development by the downregulation of p53 by a negative feedback mechanism
  • trimer formation is essential for PRL1-mediated cell growth and migration
  • play an important role in the regulation of neural function
  • PHF3 and/or PTP4A1 might play a functional role in alcohol dependence
  • PTP4A1, PTP4A2, PTP4A3 are key contributors to metastasis in several human cancers
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATF-7
  • P53, P21
  • cell & other
    REGULATION
    inhibited by sodium orthovanadate and pentamidine
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS