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FLASH GENE
Symbol CA12 contributors: mct - updated : 02-12-2010
HGNC name carbonic anhydrase XII
HGNC id 1371
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal signal sequence a CA extracellular domain including three Zn-binding histidine residues
  • a C terminal transmembrane segment
  • conjugated MetalloP
    isoforms Precursor with a truncated form (tumor associated)
    HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic-type carbonic anhydrase family
  • alpha carbonic anhydrase (CA) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text type 1 membrane protein
    basic FUNCTION
  • reversibly hydrating CO2 in cellular ion transport and pH homeostasis
  • zinc metalloenzyme responsible for acidification of the microenvironment of cancer cells
  • CA12 with CA9 are major tumor prosurvival pH-regulating enzymes, and their combined targeting shows that they hold potential as anticancer targets
  • extracellular enzyme involved in the regulation of the microenvironment acidity and tumor malignant phenotype
  • may affect the capability of invasion and migration of breast cancer cells, which may be mediated through the MAPK14 pathway
  • play a central role in osteoclast function and bone remodeling by catalyzing the formation of bicarbonate and proton from carbon dioxide
  • zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide to form a bicarbonate anion and a proton
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    Other robustly regulated by estrogen via ER alpha in breast cancer cells, and this regulation involves a distal estrogen-responsive enhancer region
    ASSOCIATED DISORDERS
    corresponding disease(s) HPCLD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in osteoclast-like cells in advanced atherosclerotic plaques
    tumoral     --other  
    commonly expressed in diffuse astrocytomas and that it might be used as a biomarker of poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS