basic FUNCTION
| . acting as a link between the recognition of specific switch regions and causation of a DNA break |
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multiple functional signaling protein involved in formation of membrane ruffling induced by signal cascade of tyrosine kinase growth factor receptors |
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may be involved in regulating migration and invasion of trophoblast cells during the processes of embryonic implantation and placentation |
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regulates the actin cytoskeleton as an effector or adaptor protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion |
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F-actin-binding, Rho GTPase-interacting protein strongly expressed in activated B cells, that is necessary for normal B-cell migration |
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regulates integrin-mediated adhesion and cell attachment |
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as SWAP70 has been shown to be the last protein to receive signals from cytokines, it is likely that there is a putative feedback signaling pathway, and that disorder of this signaling pathway can transform cells |
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restricts spontaneous maturation of dendritic cells |
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SWAP70 and DEF6 regulate hematopoietic stem cells/progenitor homeostasis, self-renewal, lineage contributions and repopulation in a distinct and mostly antagonistic manner |
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key role for SWAP70 as a scaffold for tethering the peripheral actin cage to phagosomes |
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key role for SWAP70 as the tethering factor stabilizing F-actin filaments on the surface of phagosomes in human dendritic cells by interacting both with Rho-family GTPases and the lipid phosphatidylinositol (3,4)-bisphosphate |
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essential and specific role for SWAP70 in tethering and stabilizing F-actin to the phagosomal surface in a wide range of phagocytes |
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SWAP70 and DEF6-mediated restriction of dendritic cell (DC) differentiation converges mechanistically at the NFKB1 pathway |
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SWAP70 is a protective molecule that can suppress the progression of nonalcoholic fatty liver disease by inhibiting hepatic steatosis and inflammation |