Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GNPAT contributors: mct - updated : 15-10-2013
HGNC name glyceronephosphate O-acyltransferase
HGNC id 4416
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PTS1 consensus sequence at the C terminus
  • serine-rich stretch of 11AA preceding N terminal AA sequence
  • a peroxisomal targe
  • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Gnpat
    Homologene
    FAMILY
  • Gpat/Dapat family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • playing an essential role for the biosynthesis of plasmalogens
  • catalyzing the first steps of (role in maintaining lens transparency)
  • playing a major role in etherphospholipid biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    fatty acid metabolism/ether phospholipid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RCDP2
    Susceptibility to schizophrenia
    Variant & Polymorphism other
  • block 1 (five-SNP), located between intron 2 and intron 13 of GNPAT, showed the most significant associations with schizophrenia
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice deficient in Gnpat, essential for the synthesis of ether lipids, had significant alteration of the thymic maturation of semi-invariant natural killer T cells (iNKT cells) and fewer iNKT cells in both thymus and peripheral organs, which confirmed the role of ether-bonded lipids as iNKT cell antigens