basic FUNCTION
| orphan nuclear receptor, acting as transcription activator in the absence of bound ligand |
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binds specifically to an estrogen response element and |
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activates reporter genes controlled by estrogen response elements |
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is required for early branching events of the ureteric duct that occur prior to the onset of nephrogenesis |
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is a novel downstream mediator of glucagon action in hepatic gluconeogenesis |
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potential role of ESRRG in maternal blood pressure homeostasis during pregnancy, suggesting that aberrant ESRRG expression may contribute to the pathogenesis of preeclampsia |
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ESRRG plays a role in maintenance of hearing |
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neuronal ESRRG is invoved in the metabolic adaptations required for memory formation |
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regulates testicular steroidogenesis, both directly controlling and indirectly fine-tuning the expression of steroidogenic genes |
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is a novel catabolic regulator of osteoarthritis (OA) pathogenesis |
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role for ESRRG as a critical thermoneutral maintenance factor required to prime Brown adipose tissue (BAT) for thermogenesis |
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ESRRG is a pivotal regulator in TNFSF11-mediated osteoclastogenesis |
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ESRRA and ESRRG are critical regulators of cardiac myocyte maturation, serving as transcriptional activators of adult cardiac metabolic and structural genes |