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FLASH GENE
Symbol ESRRG contributors: mct - updated : 03-06-2020
HGNC name estrogen-related receptor gamma
HGNC id 3474
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • receptor composed of a N terminal modulator domain
  • a central bipartite zinc finger DNA binding domain
  • a nuclear localization signal (NLS)
  • a C terminal ligand binding domain
  • a transactivation and dimerization domain
  • HOMOLOGY
    Homologene
    FAMILY
  • orphan receptor family
  • steroid/thyroid hormone receptor superfamily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • orphan nuclear receptor, acting as transcription activator in the absence of bound ligand
  • binds specifically to an estrogen response element and
  • activates reporter genes controlled by estrogen response elements
  • is required for early branching events of the ureteric duct that occur prior to the onset of nephrogenesis
  • is a novel downstream mediator of glucagon action in hepatic gluconeogenesis
  • potential role of ESRRG in maternal blood pressure homeostasis during pregnancy, suggesting that aberrant ESRRG expression may contribute to the pathogenesis of preeclampsia
  • ESRRG plays a role in maintenance of hearing
  • neuronal ESRRG is invoved in the metabolic adaptations required for memory formation
  • regulates testicular steroidogenesis, both directly controlling and indirectly fine-tuning the expression of steroidogenic genes
  • is a novel catabolic regulator of osteoarthritis (OA) pathogenesis
  • role for ESRRG as a critical thermoneutral maintenance factor required to prime Brown adipose tissue (BAT) for thermogenesis
  • ESRRG is a pivotal regulator in TNFSF11-mediated osteoclastogenesis
  • ESRRA and ESRRG are critical regulators of cardiac myocyte maturation, serving as transcriptional activators of adult cardiac metabolic and structural genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    estrogen
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PLK2 is a novel target of ESRRG, and this interaction is crucial for cancer cell proliferation
  • overexpression of ESRRG induced PCK1 and G6PC gene expression and glucose production in primary hepatocytes
  • ESRRG directly regulated the CYP17A1 promoter
  • ESRRG is a novel transcriptional regulator of human fibrinogen gene expression
  • functions as a negative regulator in receptor activator of TNFSF11-induced osteoclast differentiation
  • ESRRG mediates alcohol-induced hepatic lipogenesis by upregulating SREBF1 expression, which can be blunted by the inverse agonist for ESRRG
  • cell & other
    REGULATION
    activated by not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in postmenopausal vaginal mucosa
    constitutional       gain of function
    in cartilage from human osteoarthritis (OA) patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate gene for CAKUT
    Marker
  • ESRRG promoter methylation could be a diagnostic and prognostic biomarker in Laryngeal Squamous Cell Carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    control of hepatic glucose production by an ESRRG-specific inverse agonist is a new potential therapeutic approach for the treatment of type 2 diabetes
    digestiveliver 
    inverse agonist for ESRRG, may be an attractive therapeutic strategy for the treatment of alcoholic fatty liver disease
    osteoarticularboneostéoporosis
    potential therapeutic target for pathological bone loss
    ANIMAL & CELL MODELS
  • mouse embryos with a targeted inactivation of Esrrg on both alleles (Esrrg(-/-) showed agenesis of the renal papilla but normal development of the cortex and remaining medulla