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FLASH GENE
Symbol ENTPD3 contributors: mct - updated : 22/11/2008
HGNC name ectonucleoside triphosphate diphosphohydrolase 3
HGNC id 3365
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two potential transmembrane segments at the N and C termini
  • four apyrase-conserved regions which is characteristic of NTPases in the N terminal region
  • N-linked glycosylation sites processed to complex oligosaccharides
  • secondary structure five disulfide bonds
    conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to lymphoid cell activation antigen CD39
    Homologene
    FAMILY
    CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface, membrane-bound enzyme hydrolyzing extracellular nucleotides, thereby modulating purinergic signaling
  • invovedd in the control of purinergic signaling, in those cells and tissues expressing both NTPDase3alpha and NTPDase3beta
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    extracellular nucleotides
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS