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FLASH GENE
Symbol AP1S1 contributors: mct/npt - updated : 11-10-2017
HGNC name adaptor-related protein complex 1, sigma 1 subunit
HGNC id 559
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , tetramer
HOMOLOGY
interspecies ortholog to S cerevisiae,Yap17p
Homologene
FAMILY
  • adaptor complexes small subunits family
  • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text form the AP-1 assembly protein complex located at the Golgi vesicle
    basic FUNCTION
  • heterotetrameric adaptor complex AP-1 with AP1G, AP1M1/M2, AP1S1/2 transporting ligand receptor complexes from transGolgi network to lysosome
  • playing a a critical role in development of the skin and spinal cord (Montpetit 2008)
  • regulate clathrin-coated vesicle assembly, protein cargo sorting, and vesicular trafficking between organelles in eukaryotic cells (Montpetit 2008)
  • AP1S1 complex mediates protein sorting between the trans-Golgi network and early endosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles
  • heterotetrameric adaptor complex AP-1 with AP1G, AP1M1/M2, AP1S1/2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MEDNIK
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in striatum and caudate from HD patients Mazarei 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS