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FLASH GENE
Symbol TAF11 contributors: mct - updated : 14-04-2017
HGNC name TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
HGNC id 11544
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer tetramer
HOMOLOGY
Homologene
FAMILY
  • TAF2I family
  • TAF11 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the initiation of transcription by RNA polymerase 2
  • maybe involved in lung carcinoma
  • may have dual functions: a nuclear transcription function that is required for viability and development, and a cytoplasmic function in RNAi
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TAF11 heterodimerizes with TAF13 in the nucleus
  • TAF13 and TAF11 form a histone-like heterodimer that is essential for their recruitment into the general RNA polymerase II transcription factor IID (TFIID) complex
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TATA box binding (TBP)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS