Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TAF9 contributors: mct - updated : 19-05-2020
HGNC name TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
HGNC id 11542
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a P-loop nucleotide binding motif and ATPase activity
  • a TAF9 conserved C-terminal region (CRD), having a crucial role in genome-wide transcription, and required for FAM48A and TBP promoter occupancy to promote transcriptional activation
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text specifically nuclear and distributed in a widespread, diffuse nucleoplasmic pattern, excluding nucleoli, with some concentration also in Cajal bodies
    basic FUNCTION
  • functionally supports KLF1 activity by enhancing its ability to activate the beta-globin gene (Sengupta 2009)
  • TBPL1 and TAF9 regulate fatty acid composition of several classes of phospholipids
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mammalian STAGA (SUPT3H-TAF9-TADA1-KAT2A-SUPT7L acetyltransferase) a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors (Martinez 2001)
  • TBR1–CASK–TAF9 complex regulates expression of the NMDA receptor subunit 2b (GRIN2B) (Huang 2009)
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TATA box binding (TBP)
  • interacting with the herpes simplex acidic virus transactivator protein 16 (VP16) as well as with the general transcription factor TFIIB
  • interacting with COIL (carboxyl-terminal residues of coilin appear essential for the interaction)
  • interacts with a conserved beta-globin downstream promoter element, and ablation of this interaction by beta-thalassemia-causing mutations decreases its promoter activity and disables superactivation (Sengupta 2009)
  • interaction between Gli proteins and a transcription coactivator TBP-associated factor 9 (TAF9) with role in regulating Gli transactivation
  • TAF9 interacts with the oncogenic GLI family members GLI1 and GLI2 but not GLI3
  • TP53 sequesters TAF9 from GLI1, which may contribute to inhibition of GLI1 activity by TP53 and potentially impact therapeutic success of agents targeting GLI-TAF9 interactions in cancer
  • MAGEC2 directly interacted with TAF9, which may provide novel information for identifying the oncogenic functions of HCA587/MAGEE1 in tumor cells
  • key checkpoint function for the chaperonin TCP1, which specifically associates with nascent TAF5 for subsequent handover to TAF6-TAF9 and ultimate holo-TBP formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS