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FLASH GENE
Symbol TAF6 contributors: mct - updated : 02-06-2020
HGNC name TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
HGNC id 11540
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a small middle domain (TAF6M)
  • a large C-terminal domain (TAF6C)
  • HOMOLOGY
    Homologene
    FAMILY
  • TAF6 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • TAF6delta is a pro-apoptotic splice variant of the RNA polymerase II general transcription factor, TAF6, that can dictate life vs. death decisions i cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TATA box binding (TBP)
  • BCL2L11 and PMAIP1 are mitochondrial effectors of TAF6delta-driven apoptosis
  • key checkpoint function for the chaperonin TCP1, which specifically associates with nascent TAF5 for subsequent handover to TAF6-TAF9 and ultimate holo-TBP formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALYUS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS