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FLASH GENE
Symbol ATP6V0B contributors: mct - updated : 05-11-2010
HGNC name ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
HGNC id 861
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • five putative transmembrane segments (5TM)
  • a conserved glutamic and residue, essential for H+ transporting
  • HOMOLOGY
    interspecies homolog to yeast VMA16
    Homologene
    FAMILY
  • V-ATPase proteolipid subunit family
  • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • ATPase H+ transporting, vacuolar proton pump, microvesicles and other acidic organelles (lysosomes)
  • proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase
  • coupling ATP hydrolysis to proton pumping across membranes
  • conserved proton pumps that couple hydrolysis of cytosolic ATP to proton transport out of the cytosol
  • important role for physical association between aldolase and V-ATPase in the regulation of the proton pump
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS