basic FUNCTION
| having ubiquitin-protein ligase activity |
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could be implicated in tumor emergence and/or progression |
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potentially acts as a pathogenic agent in many cancers |
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by acting directly as a modifier of chromatin as well as through binding of other chromatin modifying enzymes, may influence gene expression and potentially acts as a pathogenic agent in multiple myeloma |
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major regulator of chromatin structure and transcription in t(4;14) multiple myeloma cells |
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has a role in the DNA damage response |
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critical role of WHSC1 in regulating the assembly of TP53BP1 foci at DNA lesions |
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required for proliferation of neuroblastoma cells and brain-derived neural stem cells |
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critical in maintaining the chromatin integrity |
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dimethylation of histone H3 at lysine 36 (H3K36me2) is the principal chromatin-regulatory activity of WHSC1 |
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EZH2 mediates histone H3K27 trimethylation and is associated with gene silencing, coordinately expressed and function upstream of WHSC1, which mediates H3K36 dimethylation and is associated with active transcription |
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critical role of NSD2-mediated H3K36 methylation in adipose tissue development and function |
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NSD2 is a critical epigenetic regulator for Follicular helper T (Tfh) differentiation |
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NSD2 plays a pivotal role in epigenomic maintenance and cell cycle control to prevent cellular senescence |
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NSD1, NSD2 and NSD3, have crucial roles in chromatin regulation and are implicated in oncogenesis |
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NSD2 is a critical epigenetic regulator of Treg recruitment for maternal-fetal tolerance |