basic FUNCTION
| acting as an actin-bundling protein in the absence of calcium |
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along with villin and espin is a prominent actin-bundling protein of the intestinal brush border microvilli |
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emerges as an important regulator of brush border morphology and stability through a novel role in the organization of the terminal web, possibly by connecting actin filaments to the underlying intermediate filament network |
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in contrast to other actin-bundling proteins such as ESPN, USH1C or EPS8, PLS1 is dispensable for the initial formation of stereocilia |