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FLASH GENE
Symbol PLS1 contributors: mct - updated : 01-04-2016
HGNC name plastin 1 (I isoform)
HGNC id 9090
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two actin-binding domains,
  • four calponin-homology (CH) domains
  • two EF-hand calcium-binding domains
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Pls1
    homolog to Drosophila Fim
    homolog to C.elegans Y104H12BR.1
    Homologene
    FAMILY family of actin-binding proteins
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text brush border of small intestine
    basic FUNCTION
  • acting as an actin-bundling protein in the absence of calcium
  • along with villin and espin is a prominent actin-bundling protein of the intestinal brush border microvilli
  • emerges as an important regulator of brush border morphology and stability through a novel role in the organization of the terminal web, possibly by connecting actin filaments to the underlying intermediate filament network
  • in contrast to other actin-bundling proteins such as ESPN, USH1C or EPS8, PLS1 is dispensable for the initial formation of stereocilia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • binding to actin
  • interacts with KRT19, possibly contributing to anchoring the rootlets to the keratin network
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • plastin 1-deficient mice have conspicuous ultrastructural alterations: microvilli are shorter and constricted at their base, and, strikingly, their core actin bundles lack true rootlets